Health expenditure comparison of extended-release metoprolol succinate and immediate-release metoprolol tartarate
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چکیده
منابع مشابه
Health expenditure comparison of extended-release metoprolol succinate and immediate-release metoprolol tartarate
BACKGROUND Metoprolol, a selective beta-1 blocker, is available in two different salt forms in the market - metoprolol succinate (MS) and metoprolol tartarate (MT). Both the formulations are Food and Drug Administration approved for the treatment of hypertension. Several studies have shown similar efficacies between the two salts; however, they differ in their pharmacokinetic properties and are...
متن کاملMetoprolol succinate extended release/hydrochlorothiazide combination tablets
Lowering elevated blood pressure (BP) with drug therapy reduces the risk for catastrophic fatal and nonfatal cardiovascular events such as stroke and myocardial infarction. Given the heterogeneity of hypertension as a disease, the marked variability in an individual patient's BP response, and low response rates with monotherapy, expert groups such as the Joint National Committee (JNC) emphasize...
متن کاملA factorial study of combination hypertension treatment with metoprolol succinate extended release and felodipine extended release results of the Metoprolol Succinate-Felodipine Antihypertension Combination Trial (M-FACT).
BACKGROUND Many hypertensive patients require combination therapy to achieve target blood pressure (BP). beta-Blockers and dihydropyridine calcium channel blockers are effective as monotherapy in hypertensive patients and have complementary mechanisms for lowering BP. METHODS This multicenter, randomized, placebo-controlled, unbalanced factorial study included a 4- to 5-week single-blind plac...
متن کاملEffect of Processing and Polymer Variables on Invitro Release of Metoprolol Succinate Extended Release Tablets
The present study was aimed to develop an extended release tablet of Metoprolol Succinate for the treatment of hypertension. Four extended release formulations F1-F4 were developed using varying proportions of Hydroxyl propyl methyl cellulose K100M, Sodium carboxy methyl cellulose and Eudragit L30 D55 by wet granulation. Five extended release formulations F5-F9 containing HPMC K100M and HPMC 5c...
متن کاملDesign and Optimisation of Extended Release Metoprolol Succinate Formulation Using Melt Granulation Technique
Metoprolol succinate (M.succinate), a BCS Class I drug is the most widely prescribed anti-hypertensive drug and is considered to be safe. Owing to its high solubility, fabrication of an extended release matrix formulation becomes extremely challenging. Hydrophilic matrix polymers are the preferred systems for developing an extended release formulation. However, for highly soluble drugs, it fail...
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ژورنال
عنوان ژورنال: ClinicoEconomics and Outcomes Research
سال: 2012
ISSN: 1178-6981
DOI: 10.2147/ceor.s27609